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Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials

van Thu Nguyen 1, 2, * Philippe Riviere 3, 4 Pierre Ripoll 3, 4 Julien Barnier 5 Romain Vuillemot 3, 4 Sarah Cohen-Boulakia 6 Philippe Ravaud 1, 2 Isabelle Boutron 1, 2 Covid Nma Consortium Solaf Alawadhi 7 Sihem Amer-Yahia 8 Camila Ávila 9 Aïda Bafeta 7 Julia Baudry 10 Claudia Bollig 11 Hillary Bonnet 12 Marinette Bouet 13 Guillaume Cabanac 14 Anna Chaimani 7, 2 David Chavalarias 15 Yaolong Chen 16 Astrid Chevance 7 Sarah Cohen-Boulakia 6 Emmanuel Coquery 4 Françoise Conil 4 Mauricia Davidson 7, 2 Laura de Nale 2 Declan Devane 17, 18 Elise Diard 7, 2 Bastien Doreau 13 Theodoros Evrenoglou 7, 2 Alice Fabri 19 Gilles Feron 20 Gabriel Ferrand 2 Leopold Fezeu 10 Mathilde Fouet 21 Lina Ghosn El Chall 7 Carolina Graña 7, 2 Giacomo Grasselli 22 François Grolleau 7 Mohand-Said Hacid 4 Loubna Haddy 23 Camilla Hansen 19 Ameer Hohlfeld 24 Asbjørn Hróbjartsson 19 Chantal Julia 10 Dimitris Mavridis 25 Joerg Meerpohl 26, 27 Brice Meyer 13 Nivantha Naidoo 7, 2 Theodora Oikonomidi 7 Elizabeth Pienaar 24 Fiona Quirke 28 Gabriel Rada 10, 29 Carolina Riveros 7, 2 Marie Sauvant 13 Christine Schmucker 27 Farouk Toumani 13 David Tovey 7, 2 Jun Xia 30 Xuan Yu 16 Emina Zoletic 7 Pierre Zweigenbaum 31
* Corresponding author
3 SICAL - Situated Interaction, Collaboration, Adaptation and Learning
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
7 CRESS - U1153 - Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques
UP - Université de Paris, CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
10 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
CNAM - Conservatoire National des Arts et Métiers [CNAM], INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, Université Sorbonne Paris Nord, CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
14 IRIT-IRIS - Recherche d’Information et Synthèse d’Information
IRIT - Institut de recherche en informatique de Toulouse
Abstract : Background Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against COVID-19. Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated. Method We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered. Results By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1-Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33-67]; 15-163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 post-acute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients. Conclusion This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic have passed.
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Submitted on : Monday, November 9, 2020 - 1:33:12 PM
Last modification on : Friday, November 27, 2020 - 4:05:10 PM

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van Thu Nguyen, Philippe Riviere, Pierre Ripoll, Julien Barnier, Romain Vuillemot, et al.. Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials. Journal of Clinical Epidemiology, Elsevier, 2021, 130, pp.107-116. ⟨10.1016/j.jclinepi.2020.10.010⟩. ⟨hal-02995875⟩

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