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Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials

van Thu Nguyen 1, 2, * Philippe Riviere 3, 4 Pierre Ripoll 3 Julien Barnier 5 Romain Vuillemot 3 Philippe Ravaud 1, 2, 6 Isabelle Boutron 1, 2, 6 Covid Nma Consortium Solaf Alawadhi 7 Sihem Amer-Yahia 8 Camila Ávila 9 Aïda Bafeta 7 Julia Baudry 10 Claudia Bollig 11 Hillary Bonnet 12 Marinette Bouet 13 Guillaume Cabanac 14, 15 Anna Chaimani 7, 2 David Chavalarias 16 Yaolong Chen 17 Astrid Chevance 7 Sarah Cohen-Boulakia 18 Emmanuel Coquery 19 Françoise Conil 19 Mauricia Davidson 7, 2 Laura de Nale 2 Declan Devane 20, 21 Elise Diard 7, 2 Bastien Doreau 13 Theodoros Evrenoglou 7, 2 Alice Fabri 22 Gilles Feron 23 Gabriel Ferrand 2 Leopold Fezeu 10 Mathilde Fouet 24 Lina Ghosn El Chall 7 Carolina Graña 7, 2 Giacomo Grasselli 25 François Grolleau 7 Mohand-Said Hacid 19 Loubna Haddy 26 Camilla Hansen 22 Ameer Hohlfeld 27 Asbjørn Hróbjartsson 22 Chantal Julia 10 Dimitris Mavridis 28 Joerg Meerpohl 29, 30 Brice Meyer 13 Nivantha Naidoo 7, 2 Theodora Oikonomidi 7 Elizabeth Pienaar 27 Fiona Quirke 31 Gabriel Rada 10, 32 Carolina Riveros 7, 2 Marie Sauvant 13 Christine Schmucker 30 Farouk Toumani 13 David Tovey 7, 2 Jun Xia 33 Xuan Yu 17 Emina Zoletic 7 Pierre Zweigenbaum 34
* Corresponding author
3 SICAL - Situated Interaction, Collaboration, Adaptation and Learning
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
7 CRESS - U1153 - Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques
CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
10 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
Université Sorbonne Paris Nord, CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
14 IRIT-IRIS - Recherche d’Information et Synthèse d’Information
IRIT - Institut de recherche en informatique de Toulouse
34 ILES - Information, Langue Ecrite et Signée
LIMSI - Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur
Abstract : BackgroundResearchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against COVID-19. Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated.MethodWe performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered.ResultsBy August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1-Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33-67]; 15-163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 post-acute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients.ConclusionThis living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic have passed.
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Submitted on : Monday, November 9, 2020 - 1:33:12 PM
Last modification on : Friday, December 3, 2021 - 11:42:54 AM

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van Thu Nguyen, Philippe Riviere, Pierre Ripoll, Julien Barnier, Romain Vuillemot, et al.. Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials. Journal of Clinical Epidemiology, Elsevier, 2021, 130, pp.107-116. ⟨10.1016/j.jclinepi.2020.10.010⟩. ⟨hal-02995875⟩

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