Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Patricia Santofimia-Castaño (1) , Yi Xia (2) , Wenjun Lan (3) , Zhengwei Zhou (2) , Can Huang (4) , Ling Peng (3) , Philippe Soubeyran (1) , Adrián Velázquez-Campoy (5) , Olga Abián (6) , Bruno Rizzuti (7) , José L Neira , Juan Iovanna

1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 Chongqing University [Chongqing]
3 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille
4 CAS Key Laboratory of Basic Plasma Physics
5 Unidad Asociada IQFR-CSIC-BIFI [Zaragoza, Spain]
6 University of Zaragoza - Universidad de Zaragoza [Zaragoza]
7 Unical - Università della Calabria [Arcavacata di Rende]

Domaines: Sciences du Vivant [q-bio]

Patricia Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou, Can Huang, et al.. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. Journal of Clinical Investigation, 2019, 129 (6), pp.2500 - 2513. ⟨10.1172/jci127223⟩. ⟨hal-02992816⟩