The RecQ DNA helicases in DNA repair

Kara Bernstein (1) , Serge Gangloff (2) , Rodney Rothstein (1)

1 Columbia University [New York]
2 LERA - Laboratoire d'Etudes de la Réparation de l'ADN

The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.

Domaines: Génomique, Transcriptomique et Protéomique [q-bio.GN]; Cancer

Kara Bernstein, Serge Gangloff, Rodney Rothstein. The RecQ DNA helicases in DNA repair. Annual Review of Genetics, 2010, 44 (1), pp.393-417. ⟨10.1146/annurev-genet-102209-163602⟩. ⟨hal-02990028⟩