Ruthenium-catalyzed C–H bond functionalization in cascade and one-pot transformations

Rafael Gramage-Doria (1) , Christian Bruneau (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

Ruthenium complexes are well known as remarkable pre-catalysts for challenging C-H bond functionalizations. Combining them with other types of chemical reactions in a tandem or one-pot fashion is appealing from a sustainable point of view because it gives access to new strategies to diminish steps devoted to purification and isolation of (sometimes unstable) intermediates. This non-exhaustive review highlights the different approaches enabling these technologies with a particular focus on the understanding for the compatibility of the different reaction sequences. More precisely, ruthenium-catalyzed C-H bond functionalization turned out to be compatible with several organic transformations, metal-mediated reactions and transition metal catalysis. Graphical abstract Highlights-Ruthenium complexes are compatible with one-pot and tandem transformations involving C-H bond functionalization.-Ruthenium-catalyzed C-H bond functionalization has been successfully coupled with other C-H bond functionalization reactions.-Different organic and metal-mediated transformations operate in a concerted manner with ruthenium-catalyzed C-H bond functionalization.-The merger of ruthenium-catalyzed C-H bond functionalization strategies with several transition metal catalysis is attractive for green chemistry and sustainable approaches. Ru catalysis C-H bond functionalization metal catalysis organic reactions cascade and one-pot substrates products metal meditated

Mots clés: Ruthenium catalysis; C-H bond functionalization; Cascade reactions; One-pot sequential reactions; green chemistry

Domaines: Chimie

Rafael Gramage-Doria, Christian Bruneau. Ruthenium-catalyzed C–H bond functionalization in cascade and one-pot transformations. Coordination Chemistry Reviews, 2021, 428, pp.213602. ⟨10.1016/j.ccr.2020.213602⟩. ⟨hal-02989137⟩