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Molecular Sciences Review Serotonin in Animal Cognition and Behavior

Abstract : Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions. In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom.
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https://hal.archives-ouvertes.fr/hal-02975112
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Submitted on : Thursday, October 22, 2020 - 1:43:44 PM
Last modification on : Friday, November 25, 2022 - 6:54:06 PM
Long-term archiving on: : Saturday, January 23, 2021 - 7:09:38 PM

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Julien Bacqué-Cazenave, Rahul Bharatiya, Grégory Barrière, Jean-Paul Delbecque, Nouhaila Bouguiyoud, et al.. Molecular Sciences Review Serotonin in Animal Cognition and Behavior. International Journal of Molecular Sciences, 2020, 21 (5), pp.1649. ⟨10.3390/ijms21051649⟩. ⟨hal-02975112⟩

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