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A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

Abstract : SARS-CoV-2 epidemics raises a considerable issue of public health at the planetary scale. There is a pressing urgency to find treatments based upon currently available scientific knowledge. Therefore, we tentatively propose a hypothesis which hopefully might ultimately help save lives. Based on the current scientific literature and on new epidemiological data which reveal that current smoking status appears to be a protective factor against the infection by SARS-CoV-2 [1], we hypothesize that the nicotinic acetylcholine receptor (nAChR) plays a key role in the pathophysiology of Covid-19 infection and might represent a target for the prevention and control of Covid-19 infection.
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https://hal.sorbonne-universite.fr/hal-02968179
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Submitted on : Thursday, October 15, 2020 - 2:42:29 PM
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Jean-Pierre Changeux, Zahir Amoura, Felix Rey, Makoto Miyara. A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. Comptes Rendus Biologies, 2020, 343 (1), pp.33 - 39. ⟨10.5802/crbiol.8⟩. ⟨hal-02968179⟩

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