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Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

A. Skytthe 1 S. Valensin 2 B. Jeune 1 E. Cevenini 2 Frédéric Balard 3, 4 Matthias Beekmann 5 V. Bezrukov 6 H. Blanche 7 L. Bolund 8, 9 K. Broczek 10, 11 C. Carru 12 K. Christensen 1, 13 L. Christiansen 1 J. C. Collerton 14 R. Cotichini 15 A.J.M. de Craen 16 S. Dato 17 K. Davies 14 C. de Benedictis 17 L. Deiana 12 F. Flachsbart 18 J. Gampe 19 C. Gilbault 20 E.S. Gonos 21 E. Haimes 14 A. Hervonen 22 M.A. Hurme 22 D. Janiszewska 10 M. Jylhä 22 T.B.L. Kirkwood 14 P. Kristensen 23 P. Laiho 24 A Leon. 25 A. Marchisio 12 R. Masciulli 15 A. Nebel 18 G. Passarino 17 G. Pelicci 26 L. Peltonen 24 M. Perola 24 M Poulain 20 I.M. Rea 27 J. Remacle 28 Jm Robine 29 S. Schreiber 18 M. Scurti 2 F. Sevini 2 E. Sikora 10 A. Skouteri 21 P.E. Slagboom 5, 16 L. Spazzafumo 30 M. A. Stazi 15 V. Toccaceli 15 O. Toussaint 31 O. Törnwall 24 J. W. Vaupel 19 K. Voutetakis 21 C. Franceschi 2
Abstract : In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identifiedand included in the project. In addition, 2548 younger control persons aged 50–75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.
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Submitted on : Friday, January 21, 2022 - 5:16:47 PM
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A. Skytthe, S. Valensin, B. Jeune, E. Cevenini, Frédéric Balard, et al.. Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Experimental Gerontology, Elsevier, 2011, 46 (11), pp.934-945. ⟨10.1016/j.exger.2011.08.005⟩. ⟨hal-02937385⟩



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