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Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
A. Skytthe
1
S. Valensin
2
B. Jeune
1
E. Cevenini
2
Frédéric Balard
3, 4
Matthias Beekmann
5
V. Bezrukov
6
H. Blanche
7
L. Bolund
8, 9
K. Broczek
10, 11
C. Carru
12
K. Christensen
1, 13
L. Christiansen
1
J. C. Collerton
14
R. Cotichini
15
A.J.M. de Craen
16
S. Dato
17
K. Davies
14
C. de Benedictis
17
L. Deiana
12
F. Flachsbart
18
J. Gampe
19
C. Gilbault
20
E.S. Gonos
21
E. Haimes
14
A. Hervonen
22
M.A. Hurme
22
D. Janiszewska
10
M. Jylhä
22
T.B.L. Kirkwood
14
P. Kristensen
23
P. Laiho
24
A Leon.
25
A. Marchisio
12
R. Masciulli
15
A. Nebel
18
G. Passarino
17
G. Pelicci
26
L. Peltonen
24
M. Perola
24
M Poulain
20
I.M. Rea
27
J. Remacle
28
Jm Robine
29
S. Schreiber
18
M. Scurti
2
F. Sevini
2
E. Sikora
10
A. Skouteri
21
P.E. Slagboom
5, 16
L. Spazzafumo
30
M. A. Stazi
15
V. Toccaceli
15
O. Toussaint
31
O. Törnwall
24
J. W. Vaupel
19
K. Voutetakis
21
C. Franceschi
2
Frédéric Balard 3, 4
Author Employer institution : Université de Lorraine IdHAL : frederic-balard
Matthias Beekmann 5
Author IdHAL : matthias-beekmann
V. Bezrukov 6
Author
H. Blanche 7
Author
M Poulain 20
Author IdHAL : marius-poulain
I.M. Rea 27
Author
J. Remacle 28
Author
Jm Robine 29
Author IdHAL : jm-robine ResearcherId : http://www.researcherid.com/rid/F-5439-2011 ORCID : https://orcid.org/0000-0002-4111-6195
K. Voutetakis 21
Author
C. Franceschi 2
Author
1
SDU - University of Southern Denmark (5320 Odense - Denmark)
2
University of Bologna (Via Zamboni, 33 - 40126 Bologna - Italy)
3
2L2S - Laboratoire Lorrain de Sciences Sociales (Université de Lorraine, CLSH, 23 Bd Albert 1er, BP 13397, 54015 Nancy Cedex - France)
- UL - Université de Lorraine : EA3478 (34 cours Léopold - CS 25233 - 54052 Nancy cedex - France)
4
INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
5
Netherlands Consortium for Healthy Ageing (PO Box 9600, 2300 RC Leiden - Netherlands)
- Leiden University Medical Center (LUMC) (1233 ZA, Leiden - Netherlands)
6
Institute of Gerontology [Kiev] (Ukraine)
7
CEPH - Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris] (27 rue Juliette Dodu 75010 Paris - France)
8
BGI - Beijing Genomics Institute [Shenzhen] (11F, Bei Shan Industrial Zone Yantian District Shenzhen 518083 - China)
9
Institute of Human Genetics [Aarhus] (Denmark)
10
Nencki Institute of Experimental Biology (WARSAW - Poland)
11
Medical University of Warsaw - Poland (Poland)
12
UNISS - Università degli Studi di Sassari = University of Sassari [Sassari] (via Vienna 2, 07100
Sassari,
- Italy)
13
OUH - Odense University Hospital (J. B. Winsløws Vej 4, 5000 Odense, Danemark - Denmark)
14
Newcastle University [Newcastle] (Newcastle upon Tyne NE1 7RU - United Kingdom)
15
Istituto Superiore di Sanita [Rome] (Italy)
16
Leiden University Medical Center (LUMC) (1233 ZA, Leiden - Netherlands)
17
University of Calabria (Arcavacata di Rende (CS), 87036 - Italy)
18
Institute of Clinical Molecular Biology (Kiel 24105 - Germany)
- Kiel University (Christian-Albrechts-Platz 4 24118 Kie - Germany)
19
MPIDR - Max Planck Institute for Demographic Research (Konrad-Zuse-Straße 1, 18057 Rostock - Germany)
- Max-Planck-Gesellschaft (Jägerstrasse, 10-11, D-10117 Berlin - Germany)
20
UCL - Université Catholique de Louvain = Catholic University of Louvain (Place de l'Université 1 - 1348 Louvain-La-Neuve - Belgium)
21
National Hellenic Research Foundation [Athens] (Greece)
22
Tampere School of Public Health (33014;Tampere - Finland)
- University of Tampere [Finland] (Kalevantie 4, Tampere - Finland)
23
University of Aarhus (Aarhus - Germany)
24
The National Institute for Health and Welfare (Kuopio - Finland)
- National Institute for Health and Welfare [Helsinki] (PO Box 30, FI-00271 Helsinki - Finland)
25
Research Innovation [Italy] (Italy)
26
IFOM Institute of Milan (Milan - Italy)
27
The Queen’s University of Belfast (United Kingdom)
29
CERMES3 - UMR 8211 / U988 / UM 7 - CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (7 rue Guy Môquet - BP 8 - 94801 Villejuif Cedex
Site administratif : Campus CNRS- 7, rue Guy Môquet- BP 8- 94801 Villejuif Cedex
Site Paris: CUSP (Centre universitaire des Saints-Pères)- Bâtiment Jacob (3ème étage)- 45, rue des Saints-Pères- 75270 Paris Cedex 06 - France)
- EHESS - École des hautes études en sciences sociales : UMR 8211 (54, boulevard Raspail 75006 Paris - France)
- UPD5 - Université Paris Descartes - Paris 5 : UM 7 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U988 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8211 (France)
30
Istituto Nazionale Ricovero e Cura Anziani (Italy)
31
UNamur - Université de Namur [Namur] (Rempart de la Vierge 8, 5000 Namur - Belgium)
Abstract : In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information
about health, life style, and family composition.
From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identifiedand included in the project. In addition, 2548 younger control persons aged 50–75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies).
Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.
Document type :
Journal articles
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https://hal.archives-ouvertes.fr/hal-02937385
Contributor : Frédéric Balard Connect in order to contact the contributor
Submitted on : Friday, January 21, 2022 - 5:16:47 PM
Last modification on : Monday, February 21, 2022 - 3:10:03 PM
Long-term archiving on: : Friday, April 22, 2022 - 8:58:02 PM
Contributor : Frédéric Balard Connect in order to contact the contributor
Submitted on : Friday, January 21, 2022 - 5:16:47 PM
Last modification on : Monday, February 21, 2022 - 3:10:03 PM
Long-term archiving on: : Friday, April 22, 2022 - 8:58:02 PM
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Identifiers
- HAL Id : hal-02937385, version 1
- DOI : 10.1016/j.exger.2011.08.005
Collections
2L2S | CNRS | EHESS | UNIV-PARIS5 | UNIV-PARIS | UP-SOCIETES-HUMANITES | CERMES3 | UNIV-LORRAINE | INSERM
Citation
A. Skytthe, S. Valensin, B. Jeune, E. Cevenini, Frédéric Balard, et al.. Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Experimental Gerontology, Elsevier, 2011, 46 (11), pp.934-945. ⟨10.1016/j.exger.2011.08.005⟩. ⟨hal-02937385⟩
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