Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field

Nirbhay Patil (1, 2) , Stéphanie Bonneau (2) , Frederic Joubert (2) , Anne-Florence Bitbol (2, 3) , Hélène Berthoumieux (1)

1 LPTMC - Laboratoire de Physique Théorique de la Matière Condensée
2 LJP - Laboratoire Jean Perrin
3 School of Life Sciences [Lausanne]

As the places where most of the fuel of the cell, namely, ATP, is synthesized, mitochondria are crucial organelles in eukaryotic cells. The shape of the invaginations of the mitochondria inner membrane, known as a crista, has been identified as a signature of the energetic state of the organelle. However, the interplay between the rate of ATP synthesis and the crista shape remains unclear. In this work, we investigate the crista membrane deformations using a pH-dependent Helfrich model, maintained out of equilibrium by a diffusive flux of protons. This model gives rise to shape changes of a cylindrical invagination, in particular to the formation of necks between wider zones under variable, and especially oscillating, proton flux.

Domaines: Biophysique [physics.bio-ph]

Nirbhay Patil, Stéphanie Bonneau, Frederic Joubert, Anne-Florence Bitbol, Hélène Berthoumieux. Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field. Physical Review E , 2020, 102 (2-1), pp.022401. ⟨10.1103/PhysRevE.102.022401⟩. ⟨hal-02936356⟩