Depolarization-evoked release of N-acetyl-L-aspartyl-L-glutamate from rat brain synaptosomes

Anna Pittaluga , Luis Barbeito , Valérie Serval , Gérard Godeheu , Françoise Artaud , Jacques Glowinski (1) , André Chéramy

1 INSERM U114 - Collège de France - Chaire Neuropharmacologie

Depolarization by potassium and veratridine stimulated the release of N-acetyl-L-glutamate from crude synaptosomes prepared from the rat mesencephalon and diencephalon. The potassium-evoked release of N-acetyl-L-aspartyl-L-glutamate w was calcium-dependent and the stimulatory effect of veratridine was prevented by tetrodotoxin.

Mots clés: N-Acetyl-L-aspartyl-L-glutamate; NAAG; N-acetylaspartylglutamate; N-acetylaspartylglutamic acid; Mesencephalon; Diencephalon Synaptosomes (In vitro release; Rat)

Domaines: Neurobiologie; Pharmacologie

Anna Pittaluga, Luis Barbeito, Valérie Serval, Gérard Godeheu, Françoise Artaud, et al.. Depolarization-evoked release of N-acetyl-L-aspartyl-L-glutamate from rat brain synaptosomes: Depolarization-evoked release of NAAG from rat brain synaptosomes. European Journal of Pharmacology, 1988, 158 (3), pp.263-266. ⟨10.1016/0014-2999(88)90076-3⟩. ⟨hal-02935045⟩