When a viral eruption hides another one: intrafamilial outbreak of parvovirus B19 and measles virus co-infections: case report

Claire Grolhier (1) , Charlotte Pronier (1) , Arielle Belem (2) , Julia Dina (3) , Astrid Vabret (3) , Jose-Hector Aranda Grau , Pierre Tattevin (2) , Vincent Thibault (1)

1 Irset - Institut de recherche en santé, environnement et travail
2 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
3 CHU Caen

BackgroundDespite high overall population vaccine coverage, identified clusters of persons refraining from vaccination interfere with pursued measles elimination. Clinical diagnosis of measles is often obvious due to its typical rash. Yet, febrile rashes may occur during many viral infections. Misdiagnosis of a specific primary viral infection may have severe consequences, particularly in immunocompromised subjects or pregnant women. To our knowledge, this case presentation is the first description of a measles and parvovirus B19 coinfection outbreak. Analysis of this outbreak underlines rash diagnosis difficulties and potential serology interpretation pitfalls. This case report is helpful for the clinicians in the context of measles re-emergence and proposes several methods to improve the diagnosis approach.Case presentationWe investigated an outbreak of rash in 6 out of 8 Traveler family members presenting to Rennes University Hospital (West of France). Anti-B19V and measles IgM/IgG antibodies were measured and detection of Parvovirus B19 and measles virus genomes were done on blood and/or respiratory samples. Virological investigations finally documented 6 cases of parvovirus B19 infections, including 4 associated with measles. Interestingly, in the four coinfection cases, the rash was typical of B19V primary infection for the two children but typical of measles for the two adults. Clinical diagnosis of rash may be misleading and thorough virological investigations may be required to avoid misdiagnosis.ConclusionsThis investigation first reports an intra-familial outbreak of MeV/B19V coinfections highlighting the high transmissibility of both viruses and the diagnostic challenges of dual rash-associated infections. This report also underlines the potential deleterious consequences of failure to identify measles cases, especially in a community with low vaccination coverage.

Mots clés: False positive serology; Nosocomial; Vaccine; Case report; Diagnosis

Domaines: Sciences du Vivant [q-bio]

Claire Grolhier, Charlotte Pronier, Arielle Belem, Julia Dina, Astrid Vabret, et al.. When a viral eruption hides another one: intrafamilial outbreak of parvovirus B19 and measles virus co-infections: case report. BMC Infectious Diseases, 2020, 20 (1), ⟨10.1186/s12879-020-05183-4⟩. ⟨hal-02928440⟩