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Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor

Abstract : A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying substrates, substituents or heating mode it is possible to selectively synthesize indole, indolone (1,5,6,7-tetradihydroindol-4-one) or cinnoline (5,6,7,8-tetrahydrocinnoline) derivatives in moderate to excellent yields.
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https://hal.archives-ouvertes.fr/hal-02901438
Contributor : Sabrina Touchet Connect in order to contact the contributor
Submitted on : Friday, November 20, 2020 - 8:29:03 AM
Last modification on : Tuesday, December 8, 2020 - 4:07:22 PM

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Dalel El-Marrouki, Sabrina Touchet, Abderrahmen Abdelli, Hédi M’rabet, Mohamed Lotfi Efrit, et al.. Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor. Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2020, 16, pp.1722-1731. ⟨10.3762/bjoc.16.144⟩. ⟨hal-02901438⟩

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