Transmural APD gradient synchronizes repolarization in the human left ventricular wall

Bastiaan Boukens (1) , Matthew Sulkin (2) , Chris Gloschat (1) , Fu Siong Ng (3) , Edward Vigmond (4) , Igor Efimov (1, 5)

1 GW - The George Washington University
2 WUSTL - Washington University in Saint Louis
3 Imperial College London
4 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
5 IHU-LIRYC

The duration and morphology of the T wave predict risk for ventricular fibrillation. A transmural gradient in action potential duration (APD) in the ventricular wall has been suggested to underlie the T wave in humans. We hypothesize that the transmural gradient in APD compensates for the normal endocardium-to-epicardium activation sequence and synchronizes repolarization in the human ventricular wall.

Mots clés: Human; Optical mapping; Repolarization; T wave

Domaines: Médecine humaine et pathologie; Cardiologie et système cardiovasculaire

Bastiaan Boukens, Matthew Sulkin, Chris Gloschat, Fu Siong Ng, Edward Vigmond, et al.. Transmural APD gradient synchronizes repolarization in the human left ventricular wall. Cardiovascular Research, 2015, 108 (1), pp.188-196. ⟨10.1093/cvr/cvv202⟩. ⟨hal-02886265⟩