Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation

Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation.

Jason Bayer (1) , Bastiaan Boukens (2) , Sébastien Krul (2) , Caroline Roney (3) , Antoine Driessen (2) , Wouter Berger (2) , Nicoline van den Berg (2) , Arie Verkerk (2) , Edward Vigmond (1) , Ruben Coronel (2) , Joris R de Groot (4)

1 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
2 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
3 King‘s College London
4 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam

Acetylcholine (ACh) shortens action potential duration (APD) in human atria. APD shortening facilitates atrial fibrillation (AF) by reducing the wavelength for reentry. However, the influence of ACh on electrical conduction in human atria and its contribution to AF are unclear, particularly when combined with impaired conduction from interstitial fibrosis.

Mots clés: Acetylcholine; Atria; Computational modeling; Conduction; Fibrillation; Fibrosis

Domaines: Sciences du Vivant [q-bio]; Cardiologie et système cardiovasculaire

Jason Bayer, Bastiaan Boukens, Sébastien Krul, Caroline Roney, Antoine Driessen, et al.. Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation. Frontiers in Physiology, 2019, 10, pp.1105. ⟨10.3389/fphys.2019.01105⟩. ⟨hal-02885618⟩