Decrease of spermatozoa with an unbalanced chromosome content after cell sorting in men carrying a structural chromosomal abnormality

S. El Fekih (1) , C. Tous (2) , N. Gueganic (1) , F. Brugnon (3, 4) , H Ben Ali (5) , L. Bujan (6) , N. Moinard (6) , E Caire-Tetauru (2) , M. Ajina (7) , N. Douet-Guilbert (1, 2) , F. Morel (1, 2) , A. Perrin (1, 2)

1 GGB - Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
2 CHU - BREST - Hôpital Morvan - CHRU de Brest
3 CHU Clermont-Ferrand
4 IMoST - Imagerie Moléculaire et Stratégies Théranostiques
5 CHU Farhat Hached Sousse
6 GRFH - Groupe de recherche en fertilité humaine
7 CHU Farhat Hached [Sousse]

We showed that in men with a constitutional chromosomal abnormality, DNA fragmentation was significantly higher in chromosomally unbalanced spermatozoa than in spermatozoa with a normal or balanced chromosomal content. These results could be explained by a phenomenon already described in infertile men: abortive apoptosis.

Mots clés: DNA fragmentation; chromosomally unbalanced; magnetic-activated cell separation; spermatozoa

Domaines: Sciences du Vivant [q-bio]; Cancer

S. El Fekih, C. Tous, N. Gueganic, F. Brugnon, H Ben Ali, et al.. Decrease of spermatozoa with an unbalanced chromosome content after cell sorting in men carrying a structural chromosomal abnormality. Andrology, 2019, 8 (1), pp.181-190. ⟨10.1111/andr.12643⟩. ⟨hal-02882131⟩