A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

Bradley Ridder , Derek Leishman , Matthew Bridgland-Taylor , Mohammadreza Samieegohar , Xiaomei Han , Wendy Wu , Aaron Randolph , Phu Tran , Jiansong Sheng , Timm Danker , Anders Lindqvist , Daniel Konrad , Simon Hebeisen , Liudmila Polonchuk , Evgenia Gissinger , Muthukrishnan Renganathan , Bryan Koci , Haiyang Wei , Jingsong Fan , Paul Levesque , Jae Kwagh , John Imredy , Jin Zhai , Marc Rogers , Edward Humphries , Robert Kirby , Sonja Stoelzle-Feix (1) , Nina Brinkwirth , Maria Giustina Rotordam , Nadine Becker , Søren Friis , Markus Rapedius , Tom Goetze , Tim Strassmaier , George Okeyo , James Kramer , Yuri Kuryshev , Caiyun Wu , Herbert Himmel , Gary Mirams (2) , David J. Strauss (3) , R. Bardenet (4, 5) , Zhihua Li (6)

1 Nanion Technologies
2 Computing Science Laboratory - Oxford University
3 The Life Expectancy Project
4 CNRS - Centre National de la Recherche Scientifique
5 CRIStAL - Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189
6 College of Information and Technology Science [Jilin]

Domaines: Biologie cellulaire; Statistiques [math.ST]

Bradley Ridder, Derek Leishman, Matthew Bridgland-Taylor, Mohammadreza Samieegohar, Xiaomei Han, et al.. A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm. Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩. ⟨hal-02877886⟩