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Journal articles
Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly
Abstract : Nucleobase-containing polymers are an emerging class of building blocks for the self-assembly of nanoobjects with promising applications in nanomedicine and biology. Here we present a macromolecular engineering approach to design nucleobase-containing polypeptide polymers incorporating thymine that further self-assemble in nanomaterials. Diblock and triblock copolypeptide polymers were prepared using sequential ring-opening polymerization of γ-Benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and γ-Propargyl-l-glutamate N-carboxyanhydride (PLG-NCA), followed by an efficient copper(I)-catalyzed azide alkyne cycloaddition (CuAAc) functionalization with thymidine monophosphate. Resulting amphiphilic copolymers were able to spontaneously form nanoobjects in aqueous solutions avoiding a pre-solubilization step with an organic solvent. Upon self-assembly, light scattering measurements and transmission electron microscopy (TEM) revealed the impact of the architecture (diblock versus triblock) on the morphology of the resulted nanoassemblies. Interestingly, the nucleobase-containing nanoobjects displayed free thymine units in the shell that were found available for further DNA-binding.
Cited literature [36 references]
https://hal.archives-ouvertes.fr/hal-02876032
Contributor : Olivier Sandre <>
Submitted on : Saturday, June 20, 2020 - 11:18:55 AM
Last modification on : Monday, March 8, 2021 - 12:02:02 AM
Contributor : Olivier Sandre <>
Submitted on : Saturday, June 20, 2020 - 11:18:55 AM
Last modification on : Monday, March 8, 2021 - 12:02:02 AM
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