Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers

Jonas Croissant (1) , Marie Maynadier (2) , Audrey Gallud (2) , Harmel Peindy n'Dongo (1) , Jeff Nyalosaso (1) , Gaëlle Derrien (1) , Clarence Charnay (1) , Jean-Olivier Durand (1) , Laurence Raehm (1) , Françoise Serein-Spirau (1) , Nathalie Cheminet (1) , Thibaut Jarrosson (1) , Olivier Mongin (3) , Mireille Blanchard-Desce (3) , Magali Gary-Bobo (2) , Marcel Garcia (4) , Jie Lu (5) , Fuyuhiko Tamanoi (6) , Derrick Tarn (7) , Tania Guardado-Alvarez , Jeffrey I. Zink (8)

1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 SESO - Synthèse et électrosynthèse organiques
4 IRCM - U896 Inserm - UM1 - Institut de recherche en cancérologie de Montpellier
5 Department of Chemistry
6 UCLA - Microbiology, Immunology and Molecular Genetics
7 UCLA - Department of Chemistry and Biochemistry, Exotic Materials Institute, University of California, Los Angeles
8 Department of Chemistry and Biochemistry, University of California Los Angeles

A therapy of cancer cells: Two-photon-triggered camptothecin delivery (see picture) with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.

Mots clés: azobenzene; cancer; drug delivery; mesoporous materials; two-photon excitation

Domaines: Matériaux; Chimie organique; Chimie thérapeutique; Cancer

Jonas Croissant, Marie Maynadier, Audrey Gallud, Harmel Peindy n'Dongo, Jeff Nyalosaso, et al.. Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers. Angewandte Chemie International Edition, 2013, 52 (51), pp.13813-13817. ⟨10.1002/anie.201308647⟩. ⟨hal-02875559⟩