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Rescoring ensembles of protein-protein docking poses using consensus approaches

Abstract : Scoring is a challenging step in protein-protein docking, where typically thousands of solutions are generated. Successful scoring is more often based on physicochemical evaluation of the generated interfaces and/or statistical potentials that reproduce known interface properties. Another route is offered by consensus-based rescoring, where the set of solutions is used to build statistics in order to identify recurrent solutions. We explore several ways to perform consensus-based rescoring on the ZDOCK decoy set for Benchmark 4. We show that the information of the interface size is critical for successful rescoring. We combine consensus-based rescoring with the ZDOCK native scoring function and show that this improves the initial results.
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Preprints, Working Papers, ...
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https://hal.archives-ouvertes.fr/hal-02873713
Contributor : Juliette Martin <>
Submitted on : Thursday, June 18, 2020 - 2:46:53 PM
Last modification on : Friday, June 19, 2020 - 3:30:31 AM

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Guillaume Launay, Masahito Ohue, Julia Prieto Santero, Yuri Matsuzaki, Cécile Hilpert, et al.. Rescoring ensembles of protein-protein docking poses using consensus approaches. 2020. ⟨hal-02873713⟩

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