Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands

Alina Ghinet (1) , Xavier Thuru (2) , Emilie Floquet , Joëlle Dubois (3) , Amaury Farce (4) , Benoit Rigo (5)

1 ICPAL - Institut de Chimie Pharmaceutique Albert Lespagnol
2 CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277
3 ICSN - Institut de Chimie des Substances Naturelles
4 INFINITE (Ex-Liric) - Institute for Translational Research in Inflammation - U 1286
5 UCL - Université catholique de Lille

Domaines: Chimie

Alina Ghinet, Xavier Thuru, Emilie Floquet, Joëlle Dubois, Amaury Farce, et al.. Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands. Bioorganic Chemistry, 2020, 96, pp.103643. ⟨10.1016/j.bioorg.2020.103643⟩. ⟨hal-02873632⟩