, 2018 -0511), and University of Milan intramural grants (Fondo di sviluppo unimi-linea2 -PSR2017_DIP_022_03 and PSR2019_EMARC), that granted with their expertise the high-quality of each publication. Finally, we would like to thank all funding agencies that supported our research. PG is funded by the University of Nimes. SF is funded by NIH R01NS104127