RNA sequencing analysis of activated macrophages treated with the anti-HIV ABX464 in intestinal inflammation

Laurent Manchon (1) , Karim Chébli (1) , Laura Papon (2) , Conception Paul (1) , Aude Garcel (3) , Noëlie Campos (4) , Didier Scherrer (5) , Hartmut Ehrlich , Michael Hahne (1) , Jamal Tazi (1)

1 IGMM - Institut de Génétique Moléculaire de Montpellier
2 PSL - Université Paris Sciences et Lettres
3 CRSSA - Laboratoire de virologie du Centre de Recherches du Service de Santé des Armées
4 Abivax
5 Laboratoire pharmaceutique

RNA-Seq enables the generation of extensive transcriptome information providing the capability to characterize transcripts (including alternative isoforms and polymorphism), to quantify expression and to identify differential regulation in a single experiment. To reveal the capacity of new anti-HIV ABX464 candidate in modulating the expression of genes, datasets were generated and validated using RNA-seq approach. This comprehensive dataset will be useful to deepen the comprehensive understanding of the progression of human immunodeficiency virus (HIV) associated with mucosal damage in the gastrointestinal (GI) tract and subsequent inflammation, providing an opportunity to generate new therapies, diagnoses, and preventive strategies.

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Bio-Informatique, Biologie Systémique [q-bio.QM]

Laurent Manchon, Karim Chébli, Laura Papon, Conception Paul, Aude Garcel, et al.. RNA sequencing analysis of activated macrophages treated with the anti-HIV ABX464 in intestinal inflammation. Scientific Data , 2017, 4 (1), ⟨10.1038/sdata.2017.150⟩. ⟨hal-02867138⟩