STABILISATION D'EMULSIONS DE SILICONE FONCTIONNALISEE PAR DES CYCLODEXTRINES

Ahlem Noomen , Souhaira Hbaieb (1) , Yves Chevalier (2) , Rafik Kalfat (1)

1 INRAP - Institut National de Recherche et d'Analyse Physico-Chimique
2 UCBL - Université Claude Bernard Lyon 1

Emulsions of the oil-in water type were prepared by the method of "spontaneous emulsification". The oil phase is composed of polymethylhydrosiloxane (PMHS) grafted with cyclodextrins at varying degree of substitution relative to hydrosilane groups: 20% (PMHSCD20), 30% (PMHSCD30) and 40% (PMHSCD40). The cyclodextrin was incorporated for its power to solubilize sparingly soluble compounds in water. The stability of emulsions was monitored by measuring the size distribution of particles in suspension over time. The addition of nonionic surfactants has significantly improved the stability of the preparations. A comparative study of the stability over time has been developed for different preparations depending on the nature of the oil PMHSCDx (x = 20, 30 or 40) and various nonionic surfactants. The best system, in terms of stability, is obtained with PMHSCD20 and the surfactant Pluronic® F127, which remained stable for four months at room temperature.

Mots clés: stabilité; cyclodextrine; poly(hydrométhylsiloxane); surfactant; poly(hydromethylsiloxane); cyclodextrin; stability; émulsifiant Keywords: emulsion; émulsion

Domaines: Chimie théorique et/ou physique; Polymères; Matériaux; Pharmacie galénique

Ahlem Noomen, Souhaira Hbaieb, Yves Chevalier, Rafik Kalfat. STABILISATION D'EMULSIONS DE SILICONE FONCTIONNALISEE PAR DES CYCLODEXTRINES. Journal de la Société Chimique de Tunisie, 2012, 14, pp.47-56. ⟨hal-02844534⟩