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Protein cell surface display in Gram-positive bacteria: from single protein to macromolecular protein structure

Abstract : In the course of evolution, Gram-positive bacteria, defined here as prokaryotes from the domain Bacteria with a cell envelope composed of one biological membrane (monodermita) and a cell wall composed at least of peptidoglycan and covalently linked teichoic acids, have developed several mechanisms permitting to a cytoplasmic synthesized protein to be present on the bacterial cell surface. Four major types of cell surface displayed proteins are currently recognized: (i) transmembrane proteins, (ii) lipoproteins, (iii) LPXTG-like proteins and (iv) cell wall binding proteins. The subset of proteins exposed on the bacterial cell surface, and thus interacting with extracellular milieu, constitutes the surfaceome. Here, we review exhaustively the current molecular mechanisms involved in protein attachment within the cell envelope of Gram-positive bacteria, from single protein to macromolecular protein structure.
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https://hal.inrae.fr/hal-02667211
Contributor : Migration Prodinra <>
Submitted on : Sunday, May 31, 2020 - 10:18:40 AM
Last modification on : Tuesday, June 22, 2021 - 12:02:02 PM

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Mickael Desvaux, Emilie Dumas, Ingrid Chafsey, Michel Hébraud. Protein cell surface display in Gram-positive bacteria: from single protein to macromolecular protein structure. FEMS Microbiology Letters, Wiley-Blackwell, 2006, 256 (1), pp.1-15. ⟨10.1111/j.1574-6968.2006.00122.x⟩. ⟨hal-02667211⟩

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