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The coffee genome provides insight into the convergent evolution of caffeine biosynthesis

France Denoeud 1, 2 Lorenzo Carretero-Paulet 3 Alexis Dereeper 4 Gaëtan Droc 5 Romain Guyot 6 Marco Pietrella 7 Chunfang Zheng 8 Adriana Alberti 9 François Anthony 4 Giuseppe Aprea 7 Jean-Marc Aury 9 Pascal Bento 9 Maria Bernard 9 Stephanie Bocs 5 Claudine Campa 4, 6 Alberto Cenci 4 Marie-Christine Combes 4 Dominique Crouzillat 10 Corinne da Silva 9 Loretta Daddiego 7 Fabien de Bellis 11 Stéphane Dussert 4, 6 Olivier Garsmeur 11 Thomas Gayraud 4, 6 Valentin Guignon 12 Katharina Jahn 8, 13 Veronique Jamilloux 14 Thierry Joet 4, 6 Karine Labadie 9 Tianying Lan 3, 15 Julie Leclercq 11 Maud Lepelley 10 Thierry Leroy 11 Lei-Ting Li 16 Pablo Librado 17 Loredana Lopez 7 Adriana Muñoz 18, 19 Benjamin Noel 9 Alberto Pallavicini 20 Gaetano Perrotta 7 Valérie Poncet 4, 6 David Pot 11 - Priyono 21 Michel Rigoreau 10 Mathieu Rouard 12 Julio Rozas 17 Christine Tranchant-Dubreuil 4, 6 Robert Vanburen 16 Qiong Zhang 16 Alan C Andrade 22 Xavier Argout 11 Benoit Bertrand 11 Alexandre de Kochko 4, 6 Giorgio Graziosi 20, 23 Robert J Henry 24 - Jayarama 25 Ray Ming 16 Chifumi Nagai 26 Steve Rounsley 27 David Sankoff 8 Giovanni Giuliano 28 Victor A Albert 3 Patrick Wincker 9, 2, 29 Philippe Lashermes 4
Abstract : Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although it shows no sign of the whole-genome triplication identified in Solanaceae species such as tomato, the genome includes several species-specific gene family expansions, among them N-methyltransferases (NMTs) involved in caffeine production, defense-related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis. Comparative analyses of caffeine NMTs demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.
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Submitted on : Thursday, May 28, 2020 - 5:19:50 PM
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France Denoeud, Lorenzo Carretero-Paulet, Alexis Dereeper, Gaëtan Droc, Romain Guyot, et al.. The coffee genome provides insight into the convergent evolution of caffeine biosynthesis. Science, American Association for the Advancement of Science, 2014, 345 (6201), pp.1181-1184. ⟨10.1126/science.1255274⟩. ⟨hal-02641562⟩

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