Cytoskeletal crosstalk: when three different personalities team up

Florian Huber (1) , Adeline Boire (1) , Magdalena Preciado López (1) , Gijsje H Koenderink (1)

1 AMOLF - FOM Institute for Atomic and Molecular Physics

Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there is growing evidence that the three cytoskeletal subsystems also exhibit strongly coupled functions necessary for polarization, cell migration, and mechano-responsiveness. Here we summarize this evidence from a biophysical point of view, focusing on physical (direct) interactions between the cytoskeletal elements and their influence on cell mechanics and cell migration.

Domaines: Polymères

Florian Huber, Adeline Boire, Magdalena Preciado López, Gijsje H Koenderink. Cytoskeletal crosstalk: when three different personalities team up. Current Opinion in Cell Biology, 2015, 32, pp.39-47. ⟨10.1016/j.ceb.2014.10.005⟩. ⟨hal-02638829⟩