Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

Aniek C. Bouwman (1) , Hans D. Daetwyler (2, 3) , Amanda J. Chamberlain (2) , Carla Hurtado Ponce (2, 4) , Mehdi Sargolzaei (5, 6) , Flavio S. Schenkel (5) , Goutam Sahana (7) , Armelle Gion Govignon-Gion (8) , Simon Boitard (8) , Marlies Dolezal (9) , Hubert Pausch (2, 10, 11) , Rasmus F. Brøndum (2) , Phil J. Bowman (2) , Bo Thomsen (7) , Bernt Guldbrandtsen (7) , Mogens S. Lund (7) , Bertrand Servin (8) , Dorian J. Garrick (12) , James Reecy (12) , Johanna Vilkki (13) , Alessandro Bagnato (14) , Min Wang (2, 3) , Jesse L. Hoff (15) , Robert D. Schnabel (15) , Jeremy F. Taylor (15) , Anna A. E. Vinkhuyzen (16, 17) , Frank Panitz (7) , Christian Bendixen (7) , Lars-Erik Holm (7) , Birgit Gredler (18) , Chris Hoze (19, 20) , Mekki Boussaha (19) , Marie-Pierre Sanchez (19) , Dominique Rocha (19) , Aurelien Capitan (19, 20) , Thierry Tribout (19) , Anne Barbat (19) , Pascal Croiseau (19) , Cord Drögemüller (21) , Vidhya Jagannathan (21) , Christy Vander Jagt (2) , John J. Crowley (22) , Anna Bieber (23) , Deirdre C. Purfield (24) , Donagh P. Berry (24) , Reiner Emmerling (25) , Kay-Uwe Götz (25) , Mirjam Frischknecht (18) , Ingolf Russ (26) , Johann Sölkner (26) , Curtis P. van Tassell (27) , Ruedi Fries (10) , Paul Stothard (28) , Roel F. Veerkamp (1) , Didier Boichard (19, 29) , Mike E. Goddard (4) , Ben J. Hayes (2, 17)

1 WUR - Wageningen University and Research Centre
2 Dept Econ Dev Jobs Transport & Resources
3 La Trobe University
4 University of Melbourne
5 University of Guelph
6 Semex Alliance
7 Aarhus University [Aarhus]
8 GenPhySE - Génétique Physiologie et Systèmes d'Elevage
9 Vetmeduni - University of Veterinary Medicine [Vienna]
10 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
11 ETH
12 Dept Anim Sci
13 LUKE - Natural Resources Institute Finland
14 Dept Vet Med
15 Div Anim Sci
16 Inst Mol Biosci
17 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
18 Qualitas AG
19 GABI - Génétique Animale et Biologie Intégrative
20 Allice
21 Inst Genet
22 Canadian Beef Breeds Council
23 FiBL - Research Institute of Organic Agriculture - Forschungsinstitut für biologischen Landbau
24 Teagasc - Teagasc Agriculture and Food Development Authority
25 Bavarian State Res Ctr Agr
26 BOKU - Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche]
27 USDA-ARS : Agricultural Research Service
28 University of Alberta
29 AgriBio

Stature is affected by many polymorphisms of small effect in humans(1). In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes(2,3). Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 x 10(-8)) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals

Mots clés: condition score; milk-yield; dairy cattle; human height; selection; weight; angus; hereford

Mots clés: missense mutation; plag1

Domaines: Sciences du Vivant [q-bio]; Génétique; Génétique animale; Informatique [cs]

Aniek C. Bouwman, Hans D. Daetwyler, Amanda J. Chamberlain, Carla Hurtado Ponce, Mehdi Sargolzaei, et al.. Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals. Nature Genetics, 2018, 50 (3), pp.362-367. ⟨10.1038/s41588-018-0056-5⟩. ⟨hal-02628780⟩