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Trifluoromethyl Radical Triggered Radical Cyclization of N-Benzoyl Ynamides leading to Isoindolinones

Abstract : Under photocatalytic reductive conditions, trifluoromethyl radical addition onto an ynamide followed by cyclization on a benzoyl moiety produces diverse isoindolinone platforms with good yields. The selectivity of the radical cyclization, N-benzoyl vs. N-benzyl as radical acceptor and the E/Z ratio of isomers have been rationalized by modeling.
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Submitted on : Sunday, May 24, 2020 - 10:05:10 AM
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Maud Cassé, Christian Nisole, Héloïse Dossmann, Yves Gimbert, Jean-Marie Fourquez, et al.. Trifluoromethyl Radical Triggered Radical Cyclization of N-Benzoyl Ynamides leading to Isoindolinones. SCIENCE CHINA-CHEMISTRY, 2019, ⟨10.1007/s11426-019-9627-x⟩. ⟨hal-02616094⟩

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