The novelty of phytofurans, isofurans, dihomo-isofurans and neurofurans: Discovery, synthesis and potential application

Claire Cuyamendous (1) , Aurélien de La Torre (1) , Yiu Yiu Lee (2) , Kin Sum Leung (2) , Alexandre Guy (1) , Valérie Bultel-Poncé (1) , Jean-Marie Galano (1) , Jetty Chung-Yung Lee (2) , Camille Oger (1) , Thierry Durand (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 HKU - The University of Hong Kong

Polyunsaturated fatty acids (PUFA) are oxidized in vivo under oxidative stress through free radical pathway and release cyclic oxygenated metabolites, which are commonly classified as isoprostanes and isofurans. The discovery of isoprostanes goes back twenty-five years compared to fifteen years for iso-furans, and great many are discovered. The biosynthesis, the nomenclature, the chemical synthesis of furanoids from a-linolenic acid (ALA, C18:3 n-3), arachidonic acid (AA, C20:4 n-6), adrenic acid (AdA, 22:4 n-6) and docosahexaenoic acid (DHA, 22:6 n-3) as well as their identification and implication in biological systems are highlighted in this review.

Domaines: Chimie; Chimie organique; Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Biochimie [q-bio.BM]; Chimie analytique

Claire Cuyamendous, Aurélien de La Torre, Yiu Yiu Lee, Kin Sum Leung, Alexandre Guy, et al.. The novelty of phytofurans, isofurans, dihomo-isofurans and neurofurans: Discovery, synthesis and potential application. Biochimie, 2016, pp.49-62. ⟨10.1016/j.biochi.2016.08.002⟩. ⟨hal-02593271⟩