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New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions

Stephane Kremer 1 Salem Hannoun 2 Fabrice Bonneville 3 Francoise Durand-Dubief 4 Thomas Tourdias 5 Christian Barillot 6, 7 Charles Guttmann 7 Sandra Vukusic 4 Vincent Dousset 5 Francois Cotton 8, 9, 10 R. Ameli 11 René Anxionnat 12 Bertrand Audoin 13 Arnaud Attye 14 Elise Bannier 6 Douraied Ben Salem 15 Marie-Paule Boncoeur-Martel 16 Gildas Bonhomme 17 Claire Boutet 18 Jean-Christophe Brisset 10 Frédéric Cervenansky 9 Béatrice Claise 19 Olivier Commowick 6 Jean-Marc Constans 20 Pascal Dardel 17 Hubert Desal 21 Jean-Christophe Ferré 6 Alina Gaultier 21 E. Gerardin 22 T. Glattard 23 Sylvie Grand 24 T. Grenier 23 Rémy Guillevin 25 A. Krainik 24 S. Lion 8 Nicolas Menjot de Champfleur 26 Lydiane Mondot 27 Olivier Outteryck 28 Nadya Pyatigorskaya 29 Jean-Pierre Pruvo 28 Sylvain Rabaste 8 Jean-Philippe Ranjeva 30 Jean-Amédée Roch 8 Jean-Claude Sadik 31 Dominic Sappey-Marinier 32 Julien Savatovsky 17 Jean-Yves Tanguy 33 Ayman Tourbah 34 Bruno Brochet 35 Romain Casey 35 Jerome de Seze 36 Pascal Douek 37 Francis Guillemin 38 David Laplaud 21 Christine Lebrun-Frenay 27 Lucilla Mansuy 39 Thibault Moreau 40 Javier Olaiz 32 Jean Pelletier 41 Claire Rigaud-Bully 42 Bruno Stankoff 43 Marc Debouverie 44 Gilles Edan 6 Jonathan Ciron 45 Catherine Lubetzki 29 Patrick Vermersch 28 Pierre Labauge 46 Gilles Defer 22 Eric Berger 47 Pierre Clavelou 48 O. Gout 31 Eric Thouvenot 49 Olivier Heinzlef 50 Abdullatif Al-Khedr 20 Bertrand Bourre 51 Olivier Casez 24 Philippe Cabre 52 Alexis Montcuquet 53 Alain Créange 54 Jean-Philippe Camdessanché 18 Serge Bakchine 55 A. Maurousset 56 Ivania Patry 57 Thomas de Broucker 58 Corinne Pottier 59 Jean-Philippe Neau 25 Céline Labeyrie 60 Chantal Nifle 61
6 Empenn
INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
Abstract : Purpose New multiple sclerosis (MS) disease-modifying therapies (DMTs), which exert beneficial effects through prevention of relapse, limitation of disability progression, and improvement of patients’ quality of life, have recently emerged. Nonetheless, these DMTs are not without associated complications (severe adverse events like. progressive multifocal leukoencephalopathy). Patient follow-up requires regular clinical evaluations and close monitoring with magnetic resonance imaging (MRI). Detection of new T2 lesions and potential brain atrophy measurements contribute to the evaluation of treatment effectiveness. Current MRI protocols for MS recommend the acquisition of an annual gadolinium (Gd) enhanced MRI, resulting in administration of high volume of contrast agents over time and Gd accumulation in the brain. Methods A consensus report was established by neuroradiologists and neurologists from the French Observatory of MS, which aimed at reducing the number of Gd injections required during MS patient follow-up. Recommendations The French Observatory of MS recommends the use of macrocyclic Gd enhancement at time of diagnosis, when a new DMT is introduced, at 6-month re-baseline, and when previous scans are unavailable for comparison. Gd administration can be performed as an option in case of relapse or suspicion of intercurrent disease such as progressive multifocal leukoencephalopathy. Other follow-up MRIs do not require contrast enhancement, provided current and previous MRI acquisitions follow the same standardized protocol including 3D FLAIR sequences.
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Submitted on : Monday, May 11, 2020 - 11:15:18 PM
Last modification on : Wednesday, May 5, 2021 - 2:57:05 PM

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Stephane Kremer, Salem Hannoun, Fabrice Bonneville, Francoise Durand-Dubief, Thomas Tourdias, et al.. New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions. Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2020, 47 (4), pp.250-258. ⟨10.1016/j.neurad.2020.01.083⟩. ⟨hal-02570313⟩

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