MULAN: Evaluation and ensemble statistical inference for functional connectivity

Huifang Wang (1) , Karl J. Friston (2) , Christian Bénar (3) , Marmaduke Woodman (3) , Patrick Chauvel (4) , Viktor Jirsa (3) , Christophe Bernard (5)

1 Beijing Municipal Climate Center
2 FIL - Functional Imaging Laboratory
3 INS - Institut de Neurosciences des Systèmes
4 Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition
5 navier umr 8205 - Laboratoire Navier

Many analysis methods exist to extract graphs of functional connectivity from neuronal networks. Confidence in the results is limited because, (i) different methods give different results, (ii) parameter setting directly influences the final result, and (iii) systematic evaluation of the results is not always performed. Here, we introduce MULAN (MULtiple method ANalysis), which assumes an ensemble based approach combining multiple analysis methods and fuzzy logic to extract graphs with the most probable structure. In order to reduce the dependency on parameter settings, we determine the best set of parameters using a genetic algorithm on simulated datasets, whose temporal structure is similar to the experimental one. After a validation step, the selected set of parameters is used to analyze experimental data. The final step cross-validates experimental subsets of data and provides a direct estimate of the most likely graph and our confidence in the proposed connectivity. A systematic evaluation validates our strategy against empirical stereotactic electroencephalography (SEEG) and functional magnetic resonance imaging (fMRI) data.

Domaines: Neurosciences; Informatique [cs]; Sciences cognitives; Sciences du Vivant [q-bio]

Huifang Wang, Karl J. Friston, Christian Bénar, Marmaduke Woodman, Patrick Chauvel, et al.. MULAN: Evaluation and ensemble statistical inference for functional connectivity. NeuroImage, 2018, 166, pp.167-184. ⟨10.1016/j.neuroimage.2017.10.036⟩. ⟨hal-02562257⟩