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Article Dans Une Revue Oncotarget Année : 2016

Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas

Résumé

Background: We aimed at identifying druggable molecular alterations at the RNA level from untreated HNSCC patients, and assessing their prognostic significance. Methods: We retrieved 96 HNSCC patients who underwent primary surgery. Realtime quantitative RT-PCR was used to analyze a panel of 42 genes coding for major druggable proteins. Univariate and multivariate analyses were performed to assess the prognostic significance of overexpressed genes. Results: Median age was 56 years [35-78]. Most of patients were men (80%) with a history of alcohol (70.4%) and/or tobacco consumption (72.5%). Twelve patients (12%) were HPV-positive. Most significantly overexpressed genes involved cell cycle regulation (CCND1 [27%], CDK6 [21%]), tyrosine kinase receptors (MET [18%], EGFR [14%]), angiogenesis (PGF [301%], VEGFA [14%]), and immune system (PDL1/CD274 [28%]). PIK3CA expression was an independent prognostic marker, associated with shorter disease-free survival. Conclusions: We identified druggable overexpressed genes associated with a poor outcome that might be of interest for personalizing treatment of HNSCC patient

Dates et versions

hal-02559121 , version 1 (30-04-2020)

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Marie Paule Sablin, Coraline Dubot, Jerzy T. Klijanienko, Sophie Vacher, Lamia Ouafi, et al.. Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas. Oncotarget, 2016, 7 (30), pp.47418-47430. ⟨10.18632/oncotarget.10163⟩. ⟨hal-02559121⟩
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