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Article Dans Une Revue Journal of Clinical Medicine Année : 2020

A Plasma Metabolomic Profiling of Exudative Age-Related Macular Degeneration Showing Carnosine and Mitochondrial Deficiencies

Barnabé Rondet-Courbis
  • Fonction : Auteur
Marc Ferré
Jeanne Muller
  • Fonction : Auteur
Adrien Buisset
  • Fonction : Auteur
Stéphanie Leruez
  • Fonction : Auteur
  • PersonId : 1028450
Guillaume Plubeau
  • Fonction : Auteur
Thibaut Macé
  • Fonction : Auteur
Laurie Moureauzeau
  • Fonction : Auteur
Vincent Procaccio
  • Fonction : Auteur
Delphine Mirebeau-Prunier
  • Fonction : Auteur
  • PersonId : 992772
Gilles Simard
  • Fonction : Auteur
  • PersonId : 935822
Philippe Gohier
  • Fonction : Auteur
Pascal Reynier

Résumé

To determine the plasma metabolomic profile of exudative age-related macular degeneration (AMD), we performed a targeted metabolomics study on the plasma from patients (n = 40, mean age = 81.1) compared to an age-and sex-matched control group (n = 40, mean age = 81.8). All included patients had documented exudative AMD, causing significant visual loss (mean logMAR visual acuity = 0.63), compared to the control group. Patients and controls did not differ in terms of body mass index and co-morbidities. Among the 188 metabolites analyzed, 150 (79.8%) were accurately measured. The concentrations of 18 metabolites were significantly modified in the AMD group, but only six of them remained significantly different after Benjamini-Hochberg correction. Valine, lysine, carnitine, valerylcarnitine and proline were increased, while carnosine, a dipeptide disclosing anti-oxidant and anti-glycating properties, was, on average, reduced by 50% in AMD compared to controls. Moreover, carnosine was undetectable for 49% of AMD patients compared to 18% in the control group (p-value = 0.0035). Carnitine is involved in the transfer of fatty acids within the mitochondria; proline, lysine and valerylcarnitine are substrates for mitochondrial electrons transferring flavoproteins, and proline is one of the main metabolites supplying energy to the retina. Overall, our results reveal six new metabolites involved in the plasma metabolomic profile of exudative AMD, suggesting mitochondrial energetic impairments and carnosine deficiency.
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hal-02543202 , version 1 (16-06-2020)

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Juan Manuel Chao de La Barca, Barnabé Rondet-Courbis, Marc Ferré, Jeanne Muller, Adrien Buisset, et al.. A Plasma Metabolomic Profiling of Exudative Age-Related Macular Degeneration Showing Carnosine and Mitochondrial Deficiencies. Journal of Clinical Medicine, 2020, 9 (3), pp.631. ⟨10.3390/jcm9030631⟩. ⟨hal-02543202⟩
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