Molecular Evolution and Gene Function - Archive ouverte HAL Accéder directement au contenu
Chapitre D'ouvrage Année : 2020

Molecular Evolution and Gene Function

Résumé

One of the basic questions of phylogenomics is how gene function evolves, whether among species or inside gene families. In this chapter, we provide a brief overview of the problems associated with defining gene function in a manner which allows comparisons which are both large scale and evolutionarily relevant. The main source of functional data, despite its limitations, is transcrip-tomics. Functional data provides information on evolutionary mechanisms primarily by showing which functional classes of genes evolve under stronger or weaker purifying or adaptive selection, and on which classes of mutations (e.g., substitutions or duplications). However, the example of the "ortholog conjecture" shows that we are still not at a point where we can confidently study phylogenomically the evolution of gene function at a precise scale.
Fichier principal
Vignette du fichier
chapter_4.2_robinson_rechavi.pdf (464.34 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02535687 , version 1 (10-04-2020)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

  • HAL Id : hal-02535687 , version 1

Citer

Marc Robinson-Rechavi. Molecular Evolution and Gene Function. Scornavacca, Celine; Delsuc, Frédéric; Galtier, Nicolas. Phylogenetics in the Genomic Era, No commercial publisher | Authors open access book, pp.4.2:1--4.2:20, 2020. ⟨hal-02535687⟩

Collections

PGE
489 Consultations
224 Téléchargements

Partager

Gmail Facebook X LinkedIn More