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Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients

Jean-Baptiste Delhorme 1 Jordan Ohayon Sébastien Gouy 2, 3 Catherine Genestie 4 Léopold Gaichies 5 Philippe Morice 2 Charles Honoré 2 Julio Abba Karine Abboud 6 Mohammad Alyami 7 Catherine Arvieux 8 Gerlinde Averous 9 Naoual Bakrin 7 Gisèle Balagué Vincent Barrau Houda Ben Rejeb Jean-Marc Bereder 10 Isabelle Berton-Rigaud Frédéric Bibeau 11 Isabelle Bonnefoy Dominique Bouzard Ivan Bricault 12 Cécile Brigand 1 Sebastien Carrere 13 Cécile de Chaisemartin 14 Madleen Chassang 15 Anne Chevallier Thomas Courvoisier 16 Peggy Dartigues 17 Anthony Dohan 18 Julien Dubreuil Frédéric Dumont 19 Clarisse Eveno 20 Marie Faruch-Bilfeld 21 Gwenaël Ferron 22 Juliette Fontaine Laure Fournier 23 Johan Gagnière 24 Delphine Geffroy Laurent Ghouti François-Noël Gilly 25 Laurence Gladieff 22 Olivier Glehen 26 Diane Goéré 27, 2 Aymeric Guibal Jean-Marc Guilloit 28 Frédéric Guyon Bruno Heyd 29 Christine Hoeffel 30 Constance Hordonneau 31 Sylvie Isaac 26 Peggy Jourdan-Enfer Rachid Kaci 32 Reza Kianmanesh 33 Catherine Labbe-Devilliers 34 Joëlle Lacroix 35 Bernard Lelong 36 Agnès Leroux-Broussier Yoann Lherm Réa Lo Dico 37 Gérard Lorimier 38 Caroline Malhaire 39 Frédéric Marchal 40 Pascale Mariani 41 Emilie Mathiotte Pierre Méeus 42 Eliane Mery 43 Simon Msika 44 Cédric Nadeau 45 Pablo Ortega-Deballon 46 Guillaume Passot 25 Olivier Pellet Patrice Peyrat 42 Denis Pezet 24 Nicolas Pirro 47 Marc Pocard 48 Flora Poizat 49 Jack Porcheron 50 Anaïs Poulet 51 François Quenet 52 Patrick Rat 53 Pierre Rousselot 54 Pascal Rousset 55 Hélène Senellart 56 Martine Serrano Vincent Servois 57 Olivia Sgabura Andrea Skanjeti 58 Magali Svrcek 59 Raphaël Tetreau 60 Emilie Thibaudeau 34 Yann Touchefeu 61 Jean-Jacques Tuech 62 Séverine Valmary-Degano 63 Delphine Vaudoyer 26 Stéphane Velasco 64 Véronique Verriele-Beurrier Laurent Villeneuve 65 Romuald Wernert 34 Franck Zinzindohoué 66
Abstract : Purpose: Psammocarcinoma (PK) is a rare disease of unknown origin. We aimed to report the characteristics, management and survival of patients operated on for PK within the French Network for Rare Peritoneal Malignancies (RENAPE) expert centers. Patients and methods: All consecutive cases of PK operated within all 26 RENAPE centers between 1997 and 2018 were retrospectively analyzed. Results: Twenty-five patients were identified. The median age was 53 years [range 17–78]. None of the patients had extra peritoneal metastases at diagnosis. A median of 6 cycles of carboplatin-based systemic chemotherapy was delivered in 52% preoperatively (n = 13) and 56% postoperatively (n = 14); associated with placlitaxel for 12 patients. All patients were operated on. The median PCI was 23 [0–33]. Eighty-four percent had a complete cytoreductive surgery through digestive (n = 7), spleen (n = 3), pancreas (n = 1) resections and/or multiple peritonectomies (n = 11). Five patients (20%) had intraperitoneal chemotherapy. Morbidity (Dindo-Clavien ≥3) was 12%. No postoperative death occurred. After a median follow-up of 42 months (range [2–194]), the median overall (OS) and progression-free (DFS) survival times were respectively 128 months and 31 months. Eighteen patients recurred (72%), mainly in the peritoneum (n = 16). Four of them (22%) were reoperated. The 5 and 10-year DFS rates were both 20.3%. The 5 and 10-year OS rates were 62% and 51.7%, respectively. A complete cytoreductive surgery was associated with a better OS and DFS in a univariate analysis. Conclusion: Complete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment. Recurrence remains common and new adjuvant strategies seem needed.
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https://hal.archives-ouvertes.fr/hal-02533020
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Submitted on : Monday, April 6, 2020 - 10:59:17 AM
Last modification on : Friday, July 30, 2021 - 3:16:54 AM

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Jean-Baptiste Delhorme, Jordan Ohayon, Sébastien Gouy, Catherine Genestie, Léopold Gaichies, et al.. Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients. EJSO - European Journal of Surgical Oncology, WB Saunders, 2020, 46 (5), pp.862-867. ⟨10.1016/j.ejso.2019.12.005⟩. ⟨hal-02533020⟩

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