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Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients

Jean-Baptiste Delhorme 1 Jordan Ohayon Sébastien Gouy 2, 3 Catherine Genestie 4 Léopold Gaichies 5 Philippe Morice 2 Charles Honoré 2 Julio Abba Karine Abboud 6 Mohammad Alyami 7 Catherine Arvieux 8 Gerlinde Averous 9 Naoual Bakrin 7 Gisèle Balagué Vincent Barrau Houda Ben Rejeb Jean-Marc Bereder 10 Isabelle Berton-Rigaud Frédéric Bibeau 11 Isabelle Bonnefoy Dominique Bouzard Ivan Bricault 8 Cécile Brigand 1 Sebastien Carrere 12 Cécile de Chaisemartin 13 Madleen Chassang 14 Anne Chevallier Thomas Courvoisier 15 Peggy Dartigues 16 Anthony Dohan 17 Julien Dubreuil Frédéric Dumont 18 Clarisse Eveno 19 Marie Faruch-Bilfeld 20 Gwenaël Ferron 21 Juliette Fontaine Laure Fournier 22 Johan Gagnière 23 Delphine Geffroy Laurent Ghouti François-Noël Gilly 24 Laurence Gladieff 21 Olivier Glehen 25 Diane Goéré 26, 2 Aymeric Guibal Jean-Marc Guilloit 27 Frédéric Guyon Bruno Heyd 28 Christine Hoeffel 29 Constance Hordonneau 30 Sylvie Isaac 25 Peggy Jourdan-Enfer Rachid Kaci 31 Reza Kianmanesh 32 Catherine Labbe-Devilliers 33 Joëlle Lacroix 34 Bernard Lelong 35 Agnès Leroux-Broussier Yoann Lherm Réa Lo Dico 36 Gérard Lorimier 37 Caroline Malhaire 38 Frédéric Marchal 39 Pascale Mariani 40 Emilie Mathiotte Pierre Méeus 41 Eliane Mery 42 Simon Msika 43 Cédric Nadeau 44 Pablo Ortega-Deballon 45 Guillaume Passot 24 Olivier Pellet Patrice Peyrat 41 Denis Pezet 23 Nicolas Pirro 46 Marc Pocard 47 Flora Poizat 48 Jack Porcheron 49 Anaïs Poulet 50 François Quenet 51 Patrick Rat 52 Pierre Rousselot 53 Pascal Rousset 54 Hélène Senellart 55 Martine Serrano Vincent Servois 56 Olivia Sgabura Andrea Skanjeti 57 Magali Svrcek 58 Raphaël Tetreau 59 Emilie Thibaudeau 33 Yann Touchefeu 60 Jean-Jacques Tuech 61 Séverine Valmary-Degano 62 Delphine Vaudoyer 25 Stéphane Velasco 63 Véronique Verriele-Beurrier Laurent Villeneuve 64 Romuald Wernert 33 Franck Zinzindohoué 65 
Abstract : Purpose: Psammocarcinoma (PK) is a rare disease of unknown origin. We aimed to report the characteristics, management and survival of patients operated on for PK within the French Network for Rare Peritoneal Malignancies (RENAPE) expert centers. Patients and methods: All consecutive cases of PK operated within all 26 RENAPE centers between 1997 and 2018 were retrospectively analyzed. Results: Twenty-five patients were identified. The median age was 53 years [range 17–78]. None of the patients had extra peritoneal metastases at diagnosis. A median of 6 cycles of carboplatin-based systemic chemotherapy was delivered in 52% preoperatively (n = 13) and 56% postoperatively (n = 14); associated with placlitaxel for 12 patients. All patients were operated on. The median PCI was 23 [0–33]. Eighty-four percent had a complete cytoreductive surgery through digestive (n = 7), spleen (n = 3), pancreas (n = 1) resections and/or multiple peritonectomies (n = 11). Five patients (20%) had intraperitoneal chemotherapy. Morbidity (Dindo-Clavien ≥3) was 12%. No postoperative death occurred. After a median follow-up of 42 months (range [2–194]), the median overall (OS) and progression-free (DFS) survival times were respectively 128 months and 31 months. Eighteen patients recurred (72%), mainly in the peritoneum (n = 16). Four of them (22%) were reoperated. The 5 and 10-year DFS rates were both 20.3%. The 5 and 10-year OS rates were 62% and 51.7%, respectively. A complete cytoreductive surgery was associated with a better OS and DFS in a univariate analysis. Conclusion: Complete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment. Recurrence remains common and new adjuvant strategies seem needed.
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Submitted on : Monday, April 6, 2020 - 10:59:17 AM
Last modification on : Friday, September 9, 2022 - 10:20:08 AM

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Jean-Baptiste Delhorme, Jordan Ohayon, Sébastien Gouy, Catherine Genestie, Léopold Gaichies, et al.. Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients. EJSO - European Journal of Surgical Oncology, WB Saunders, 2020, 46 (5), pp.862-867. ⟨10.1016/j.ejso.2019.12.005⟩. ⟨hal-02533020⟩

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