Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques

Xiaoying Shen (1) , Willy Bogers , Nicole Yates , Guido Ferrari , Antu Dey (2) , William Williams , Frederick Jaeger , Kevin Wiehe , Sheetal Sawant , S. Munir Alam , Celia Labranche (3) , David C. Montefiori (1) , Loïc M Martin (4, 5) , Indresh Srivastava (2) , Jonathan Heeney , Susan W Barnett (6) , Georgia D. Tomaras (1)

1 Duke Human Vaccine Institute [Durham, North Carolina, USA]
2 Novartis Vaccines and Diagnostics [Siena]
3 Duke University Medical Center
4 SIMoS - Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO)
5 MTS - Médicaments et Technologies pour la Santé
6 Novartis Vaccines

Domaines: Chimie thérapeutique; Médecine vétérinaire et santé animale; Biochimie [q-bio.BM]; Immunothérapie; Vaccinologie; Virologie

Xiaoying Shen, Willy Bogers, Nicole Yates, Guido Ferrari, Antu Dey, et al.. Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques. Journal of Virology, 2017, 91 (19), ⟨10.1128/JVI.00401-17⟩. ⟨hal-02530935⟩