Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1

Neelakshi Gohain , William Tolbert , Priyamvada Acharya (1) , Lei Yu (2) , Tongyun Liu , Pingsen Zhao , Chiara Orlandi (3) , Maria Visciano , Roberta Kamin-Lewis , Mohammad Sajadi , Loïc M Martin (4) , James Robinson , Peter D. Kwong (1) , Anthony Devico , Krishanu Ray , George Lewis , Marzena Pazgier

1 Vaccine Research Center
2 SPL - Signal Processing Laboratory
3 Department of Biomolecular Sciences
4 CEA - Commissariat à l'énergie atomique et aux énergies alternatives

Domaines: Cristallographie; Chimie thérapeutique; Biochimie [q-bio.BM]; Biologie structurale [q-bio.BM]; Immunothérapie; Vaccinologie

Neelakshi Gohain, William Tolbert, Priyamvada Acharya, Lei Yu, Tongyun Liu, et al.. Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. Journal of Virology, 2015, 89 (17), pp.8840-8854. ⟨10.1128/JVI.01232-15⟩. ⟨hal-02530901⟩