Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

P. Acharya , T. Luongo , I. Georgiev , J. Matz , S. Schmidt , M. Louder , P. Kessler (1) , Y. Yang (2) , K. Mckee , S. O'Dell , L. Chen , D. Baty (3) , P. Chames , Loïc M Martin (1) , J. Mascola , P. Kwong

1 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
2 ESRF - European Synchrotron Radiation Facility
3 Ninewells Hospital and Medical School [Dundee]

Domaines: Cristallographie; Chimie thérapeutique; Biochimie [q-bio.BM]; Biologie structurale [q-bio.BM]; Immunothérapie

P. Acharya, T. Luongo, I. Georgiev, J. Matz, S. Schmidt, et al.. Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites. Journal of Virology, 2013, 87 (18), pp.10173-10181. ⟨10.1128/JVI.01332-13⟩. ⟨hal-02530765⟩