Ultrasound for Drug Synthesis: A Green Approach

Micheline Draye (1) , Gregory Chatel (1) , Romain Duwald (1)

1 LCME - Laboratoire de Chimie Moléculaire et Environnement

This last century, the development of new medicinal molecules represents a real breakthrough in terms of humans and animal life expectancy and quality of life. However, this success is tainted by negative environmental consequences. Indeed, the synthesis of drug candidates requires the use of many chemicals, solvents, and processes that are very hazardous, toxic, energy consuming, expensive, and generates a large amount of waste. Many large pharmaceutical companies have thus moved to using green chemistry practices for drug discovery, development, and manufacturing. One of them is the use of energy-efficient activation techniques, such as ultrasound. This review summarizes the latest most representative works published on the use of ultrasound for sustainable bioactive molecules synthesis.

Mots clés: sonochemistry; sustainable drugs synthesis; ultrasound; green oxidations; green reductions; enzymatic transformations

Mots clés: oxydation; sonochimie; ultrasound; synthèse de médicaments; transformations enzymatiques; chimie verte; procédés durables

Domaines: Chimie; Chimie organique

Micheline Draye, Gregory Chatel, Romain Duwald. Ultrasound for Drug Synthesis: A Green Approach. Pharmaceuticals, 2020, 13 (2), pp.23. ⟨10.3390/ph13020023⟩. ⟨hal-02527201⟩