Antibiotic resistance: Tools for effective translational research

Marie-Cécile Ploy (1) , Antoine Andremont (2) , Bruno Valtier (3) , Claire Le Jeunne (4) , Catherine Dumartin (5, 6) , Didier Guillemot (7, 8) , Alain Bousquet‐mélou (9) , Christian Brun-Buisson (7) , Bruno Coignard (10) , Didier Concordet (9) , William Couet (11) , Joanie del Bano (12, 13) , Romain Guilhaumou (12, 13, 14) , Cyril Guyard (15) , Evelyne Jouvin-Marche (16) , Solen Kernéis (4, 7) , Mohamed Khelifa (17) , Mourez Michaël (18) , Marie-Clémence Verdier (19, 20)

1 RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
2 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
3 Pfizer
4 Hôpital Cochin [AP-HP]
5 BPH - Bordeaux population health
6 CHU Bordeaux
7 B2PHI - Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses
8 Hôpital Raymond Poincaré [AP-HP]
9 InTheRes - Innovations Thérapeutiques et Résistances
10 Direction des maladies infectieuses - Infectious Diseases Division [Saint-Maurice]
11 PHAR [Poitiers] - Pharmacologie des anti-infectieux
12 Service de Pharmacologie Clinique [Hôpital de la Timone - APHM]
13 CRPV-Marseille - Centre régional de pharmacovigilance de Marseille Provence Corse [CHU de Marseille]
14 INS - Institut de Neurosciences des Systèmes
15 BIOASTER Microbiology Technology Institute [Lyon]
16 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
17 Sanofi-Aventis R&D
18 Evotec
19 CIC - Centre d'Investigation Clinique [Rennes]
20 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]

The rising emergence of bacterial resistances has led to a crisis which threatens human, animal and environmental health. The impact of the emergency is enormous in terms of public health and economics. Although there is a global awareness of the warnings and programmes supporting innovative actions to combat fight against antibiotic resistance, it must be admitted that proposed new antibiotics fail to find the economic profitability necessary for them to reach the market and become available for patients and the community. Moreover, it is necessary to develop tools/indicators to define effective interventions against antibiotic resistance. The work of the think-tank reported in this article concentrated on two aspects of translational research: - prevention and the impact on health of the antibiotic resistance issue, and - the specific requirements of clinical research leading to innovation in the fight against antibiotic resistance. This article, which reflects the thoughts of a group of French experts, proposes directly operational solutions which could be rapidly implemented and radically transform the quality and quantity of our resources available for the combat.

Mots clés: Innovation; Antibio-resistance; Impact; Stewardship; Microbiota

Domaines: Sciences du Vivant [q-bio]

Marie-Cécile Ploy, Antoine Andremont, Bruno Valtier, Claire Le Jeunne, Catherine Dumartin, et al.. Antibiotic resistance: Tools for effective translational research. Thérapie, 2020, Giens Workshops 2019, 75 (1), pp.7-12. ⟨10.1016/j.therap.2019.12.003⟩. ⟨hal-02516924⟩