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Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications

Abstract : While one of the major clinical and scientific challenges in the management of implant-related infections and post-operative complications after surgery is the application of new techniques, a new approach is pertinent in the design of medical implants to reduce bacterial infections. We have designed and tested antibiotic-containing biocomposite thin films of polylactic acid (PLA), and coralline-derived hydroxyapatite (HAp) as controlled drug delivery systems for the treatment of dental, orthopaedic and neural implant-related post-operative infections. These films can be applied to complicated designs of dental, miniaturized neural devices, cochlear or total hip replacement (THR) implants by spray or dip-coating techniques. Current results reveal that the devices could release antibiotic in a controlled manner to prevent significantly bacterial growth and biofilm production. Hydroxyapatite within the composites controls the release rate and also supplies minerals, such as calcium Ca2+ and phosphate PO42− ions, which are essential minerals for bone tissue regeneration. It is concluded from the physical, mechanical and biological properties that these coatings and devices could easily be utilized in a wide range of biomedical applications.
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https://hal.archives-ouvertes.fr/hal-02498506
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Submitted on : Wednesday, March 4, 2020 - 3:10:33 PM
Last modification on : Monday, December 28, 2020 - 10:22:04 AM
Long-term archiving on: : Friday, June 5, 2020 - 2:38:59 PM

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Innocent J. Macha, Ipek Karacan, Besim Ben-Nissan, Sophie Cazalbou, Wolfgang H. Müller. Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications. SN Applied Sciences, Springer Verlag, 2019, 1, pp.68. ⟨10.1007/s42452-018-0064-1⟩. ⟨hal-02498506⟩

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