The case series method.

La méthode de la série de cas

Mounia N. Hocine (1) , Michel Chavance (2)

1 Chaire d'Hygiène et sécurité du travail
2 CESP - Centre de recherche en épidémiologie et santé des populations

The case series method was developed by Farrington (1995) to investigate the strength of association between a time-varying exposure and an acute rare potentially recurrent event, using cases only. It can be used when the exposure can only be causally related to the event during a limited period of time. It has been widely used in pharmaco-epidemiology, particularly in the study of vaccine safety. The method is derived from a Poisson model by conditioning on the individual total number of events and its exposure history. As a consequence of this conditioning, the effects of fixed covariates cancel out, so that the method has a particular advantage as compared with cohort and case-control studies.

Mots clés: Case series; self-control; acute event; transient exposures; vaccination Série de cas; auto-appariement; événement à survenue aigüe; exposition intermittente; vaccination

Domaines: Santé publique et épidémiologie

Mounia N. Hocine, Michel Chavance. La méthode de la série de cas. Epidemiology and Public Health = Revue d'Epidémiologie et de Santé Publique, 2010, 58 (6), pp.435-40. ⟨10.1016/j.respe.2010.06.168⟩. ⟨inserm-00498856⟩