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Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus

Abstract : Using fluorescence in situ hybridization, we determined the ploidy off our species of Leishmania: L.infantum, L.donovani, L.tropicaand and L.amazonensis. We found that each cell in a strain possesses a combination of mono-, di- and trisomies for all chromosomes; ploidy patterns were different among all strains/species. These results extend those we previously described in L. major, demonstrating that mosaic aneuploidy is a genetic feature widespread to the Leishmania genus. In addition to the genetic consequences induced by this mosaicism, the apparent absence of alternation between haploid/diploid stages questions the modality of genetic exchange in Leishmania sp.
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Laurence Lachaud, Nathalie Bourgeois, Nada Kuk, Christelle Morelle, Lucien Crobu, et al.. Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus. Microbes and Infection, Elsevier, 2014, 16 (1), pp.61-66. ⟨10.1016/j.micinf.2013.09.005⟩. ⟨hal-02496197⟩



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