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Article Dans Une Revue Journal of materials chemistry‎ B Année : 2013

Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery

Résumé

We report Lipid OligoNucleotide conjugates (LONs) bearing either two or three hydrophobic chains. LONs self-assemble into micellar aggregates, which provide a suitable reservoir for hydrophobic drug such as paclitaxel. Our results 10 demonstrate that the composition of the LONs both in terms of the lipid and the oligonucleotide sequence impact their ability to host lipophilic molecules. Interestingly, binding of the complementary oligonucleotide selectively induces the release of part of the drug payload of the aggregates. These 15 LON based micelles, which efficiently host hydrophobic drugs represent an original stimuli-responsive drug delivery system.
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Dates et versions

hal-02484550 , version 1 (19-02-2020)

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Oleksandr Pokholenko, Arnaud Gissot, Brune Vialet, Katell Bathany, Alain Thiery, et al.. Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery. Journal of materials chemistry‎ B, 2013, 1 (39), pp.5329-5334. ⟨10.1039/C3TB20357C⟩. ⟨hal-02484550⟩
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