A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Ling Ding (1) , Zhenbin Lyu (1) , Aura Tintaru (2) , Erik Laurini (3) , Domenico Marson (3) , Beatrice Louis (4) , Ahlem Bouhlel (4, 5, 6) , Laure Balasse (4, 5, 6) , Samantha Fernandez (5, 4) , Philippe Garrigue (4, 5, 6) , Eric Mas (4) , Suzanne Giorgio (1) , Sabrina Pricl (3) , Benjamin Guillet (6) , Ling Peng (1)

1 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille
2 ICR - Institut de Chimie Radicalaire
3 Università degli studi di Trieste = University of Trieste
4 INSERM - Institut National de la Santé et de la Recherche Médicale
5 CERIMED - Centre Européen de Recherche en Imagerie médicale
6 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research

Bioimaging has revolutionized modern medicine, and nanotechnology can offer further specific and sensitive imaging. We report here an amphiphilic dendrimer able to self-assemble into supramolecular nanomicelles for effective tumor detection using SPECT radioimaging. This highlights the promising potential of supramolecular dendrimer platforms for biomedical imaging.

Domaines: Matériaux; Chimie thérapeutique; Sciences du Vivant [q-bio]; Chimie

Ling Ding, Zhenbin Lyu, Aura Tintaru, Erik Laurini, Domenico Marson, et al.. A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging. Chemical Communications, 2020, 56 (2), pp.301-304. ⟨10.1039/c9cc07750b⟩. ⟨hal-02480314⟩