FDG Brain PET/CT Revealing Bilateral Thalamostriatal Activation During a Symptomatic Episode in a Patient With Kleine-Levin Syndrome

Clément Drouet (1) , Olivier Morel (2, 3) , Antoine Verger (4, 3) , Eric Guedj (5) , Hatem Boulahdour (6)

1 UL - Université de Lorraine
2 Service d'Obstétrique et de Gynécologie [CHRU Nancy]
3 IADI - Imagerie Adaptative Diagnostique et Interventionnelle
4 Service de Médecine Nucléaire [CHRU Nancy]
5 Service Central de Biophysique et de Médecine Nucléaire
6 NIT / NANOMEDECINE - Nanomédecine, imagerie, thérapeutique - UFC (UR 4662)

We report the case of a 14-year-old girl with clinically diagnosed Kleine-Levin syndrome. Electroencephalogram and brain MRI were unremarkable. An FDG PET/CT scan was acquired during a symptomatic episode, while she was asleep, and another PET scan was obtained when she was asymptomatic, awake, and quiet. Comparison of both examinations demonstrated a bilateral activation of thalami, caudate nuclei, and lenticular nuclei. These findings may be linked to the implication of thalamostriatal structures in the regulation of sleep and wakefulness.

Domaines: Médecine humaine et pathologie

Clément Drouet, Olivier Morel, Antoine Verger, Eric Guedj, Hatem Boulahdour. FDG Brain PET/CT Revealing Bilateral Thalamostriatal Activation During a Symptomatic Episode in a Patient With Kleine-Levin Syndrome. Clinical Nuclear Medicine, 2017, 42 (5), pp.e261-e262. ⟨10.1097/RLU.0000000000001616⟩. ⟨hal-02479850⟩