Skip to Main content Skip to Navigation
Journal articles

Added value of 18 F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Mathieu Ceccaldi 1, 2 Thérèse Jonveaux 3 Antoine Verger 4 Pierre Krolak-Salmon 5 Claire Houzard 5 Olivier Godefroy 6 Trevor Shields 7 Audrey Perrotin Rossella Gismondi Santiago Bullich Aleksandar Jovalekic Nicola Raffa Florence Pasquier 8 Franck Semah 9 Bruno Dubois 10 Marie-Odile Habert 11 David Wallon 12 Mathieu Chastan 13 Pierre Payoux 14 Eric Guedj 15 Olivier Félician 16 Mira Didic 17 Claude Gueriot Lejla Koric 17 Radka Kletchkova-Gantchev Daniela Andriuta Agnès Devendeville Diane Dupuis Ingrid Binot Mélanie Barbay 18 Marc-Etienne Meyer Véronique Moullard Eloi Magnin 19 Ludivine Chamard 19 Sophie Haffen Olivier Morel 20 Clément Drouet 21 Hatem Boulahdour 22 Mathilde Sauvée 23 Philippe Goas 24 Solène Querellou-Lefranc Vincent de la Sayette 25 Julien Cogez Pierre Branger 25 Denis Agostini 26 Alain Manrique 27 Olivier Rouaud 28 Yannick Bejot 29 Agnès Jacquin-Piques 30 Inna Dygai-Cochet 31 Alina Berriolo-Riedinger 32 Olivier Moreaud 33 Céline Gallazzani Crépin Stéphanie Bombois 34 Thibaud Lebouvier 8 Marie-Anne Mackowiak-Cordoliani Vincent Deramecourt 35 Adeline Rollin-Sillaire 36 Pascaline Cassagnaud-Thuillet Yaohua Chen 34 Grégory Petyt 34 Denis Fédérico 37 Keren Liora Danaila Yves Guilhermet Christophe Magnier 38 Zaza Makaroff 39 Isabelle Rouch 40 Jing Xie 41 Caroline Roubaud Marie-Hélène Coste Kenny David Alain Sarciron Aziza Sediq Waissi Christian Scheiber Audrey Gabelle-Deloustal 42 Karim Bennys 43 Cecilia Marelli 44 Lynda Touati Denis Mariano-Goulart 45 Delphine de Verbizier-Lonjon Athanase Benetos 46 Anna Kearney-Schwartz 47 Christine Perret-Guillaume 48 Martine Vercelletto 49 Claire Boutoleau-Bretonnière 50 Hélène Pouclet-Courtemanche Nathalie Wagemann Amandine Pallardy 51 Jacques Hugon 52 Claire Paquet 52 Julien Dumurgier 52 Pascal Millet 53 Mathieu Queneau Stéphane Epelbaum 54 Marcel Levy 10 Jean-Luc Novella 55 Yacine Jaidi Dimitri Papathanassiou David Morland Serge Belliard 56 Anne Salmon 47 Florence Lejeune 57 Didier Hannequin 58 Olivier Martinaud 12 Aline Zarea 59 Jérémie Pariente 60 Claire Thalamas 61 Monique Galitzky-Gerber Anne-Marie Tricoire Ricard Fabienne Calvas Emilie Rigal 62 Anne Hitzel 13 Julien Delrieu 63 Pierre-Jean Ousset 64 Françoise Lala Nathalie Sastre-Hengan Andrew Stephens
28 GEPEA-OSE - Optimisation - Système - Energie
GEPEA - Laboratoire de génie des procédés - environnement - agroalimentaire
Abstract : Introduction: Although some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting. Methods: This multicenter study was performed at French tertiary memory clinics in patients presenting with most complex clinical situations (i.e., early-onset, atypical clinical profiles, suspected mixed etiological conditions, unexpected rate of progression), for whom cerebrospinal fluid analysis was indicated but either not feasible or considered as noncontributory (ClinicalTrials.gov: NCT02681172). Results: Two hundred five patients were enrolled with evaluable florbetaben PET scans; 64.4% of scans were amyloid positive. PET results led to changed diagnosis and improved confidence in 66.8% and 81.5% of patients, respectively, and altered management in 80.0% of cases. Discussion: High-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02479805
Contributor : Eric Guedj <>
Submitted on : Friday, February 14, 2020 - 4:52:36 PM
Last modification on : Friday, September 18, 2020 - 2:34:49 PM

Links full text

Identifiers

Citation

Mathieu Ceccaldi, Thérèse Jonveaux, Antoine Verger, Pierre Krolak-Salmon, Claire Houzard, et al.. Added value of 18 F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Elsevier, 2018, 14 (3), pp.293-305. ⟨10.1016/j.jalz.2017.09.009⟩. ⟨hal-02479805⟩

Share

Metrics

Record views

466