Bioactive Glass/Polycaprolactone Hybrid with a Dual Cortical/Trabecular Structure for Bone Regeneration - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ACS Applied Bio Materials Année : 2019

Bioactive Glass/Polycaprolactone Hybrid with a Dual Cortical/Trabecular Structure for Bone Regeneration

Résumé

Organic-inorganic hybrid biomaterials stand as a promise for combining bone bonding and bone mineral-forming ability, stimulation of osteogenic cells and adequate mechanical properties. Bioactive glass (BG)polycaprolactone (PCL) hybrids are of special interest as they gather the ability of BG to enhance osteoblast-mediated bone formation with the slow degradation rate and the toughness of PCL. In this study, BG-PCL hybrids were synthesized in the form of scaffold owing a dual cortical/trabecular structure mimicking the bone architecture. Their biological potential was evaluated both in vitro using rat primary osteoblasts (RPO) and in vivo in a mice model of critical-size calvarial defects. BG-PCL were compared to Lubboc TM (BTB), a commercial purified bovine xenograft widely used in orthopedics and periodontal procedures and known for its efficiency. BG-PCL hybrids were found to facilitate RPO adhesion at their surface and to enhance RPO differentiation when compared to BTB. In vivo micro-CT study demonstrates a higher bone ingrowth with BG-PCL scaffolds and a complete chemical conversion of remaining BG-PCL after 3 months 2 implantation, while histological data show the vascularization of BG-PCL scaffolds and confirm the well-advanced bone regeneration with ongoing remodeling. Finally, we evidence the complete chemical conversion of remaining BG-PCL into a bone-like mineral.
Fichier principal
Vignette du fichier
Article Granel_revCB_04-07-19.pdf (1.82 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04056742 , version 1 (03-04-2023)

Identifiants

Citer

Henri Granel, Cédric Bossard, Anne-Margaux Collignon, Fabien Wauquier, Julie Lesieur, et al.. Bioactive Glass/Polycaprolactone Hybrid with a Dual Cortical/Trabecular Structure for Bone Regeneration. ACS Applied Bio Materials, 2019, 2 (8), pp.3473-3483. ⟨10.1021/acsabm.9b00407⟩. ⟨hal-04056742⟩
89 Consultations
39 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More