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Article Dans Une Revue Alcohol and Alcoholism Année : 2012

Osteocyte apoptosis and lipid infiltration as mechanisms of alcohol-induced bone loss

Rustem Uzbekov
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Résumé

Aims: We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss. Methods and results: After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels. Conclusion: These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or 'bone steatosis', is correlated with lipid accumulation in bone marrow and blood micro-vessels.

Dates et versions

hal-02476500 , version 1 (12-02-2020)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Delphine B. Maurel, Stéphane Pallu, Christelle Jaffré, Nicola Fazzalari, Nathalie Boisseau, et al.. Osteocyte apoptosis and lipid infiltration as mechanisms of alcohol-induced bone loss. Alcohol and Alcoholism, 2012, 47 (4), pp.413-422. ⟨10.1093/alcalc/ags057⟩. ⟨hal-02476500⟩
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