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Article Dans Une Revue FEBS Journal Année : 2020

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

Elodie Ramond
Bianca Petrignani
  • Fonction : Auteur
Jan Paul Dudzic
  • Fonction : Auteur
Jean-Philippe Boquete
  • Fonction : Auteur
Shu Kondo
  • Fonction : Auteur
Bruno Lemaitre
  • Fonction : Auteur

Résumé

In animals, growth is regulated by the complex interplay between paracrine and endocrine signals. When food is scarce, tissues compete for nutrients, leading to critical resource allocation and prioritization. Little is known about how the immune system maturation is coordinated with the growth of other tissues. Here, we describe a signaling mechanism that regulates the number of hemocytes (blood cells) according to the nutritional state of the Drosophila larva. Specifically, we found that a secreted protein, NimB5, is produced in the fat body upon nutrient scarcity downstream of metabolic sensors and ecdysone signaling. NimB5 is then secreted and binds to hemocytes to down-regulate their proliferation and adhesion. Blocking this signaling loop results in conditional lethality when larvae are raised on a poor diet, due to excessive hemocyte numbers and insufficient energy storage. Similar regulatory mechanisms shaping the immune system in response to nutrient availability are likely to be widespread in animals.

Dates et versions

hal-02476327 , version 1 (12-02-2020)

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Citer

Elodie Ramond, Bianca Petrignani, Jan Paul Dudzic, Jean-Philippe Boquete, Mickaël Poidevin, et al.. The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila. FEBS Journal, 2020, ⟨10.1111/febs.15237⟩. ⟨hal-02476327⟩
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