An oxidatively damaged G-quadruplex/hemin DNAzyme

Jiawei Wang (1) , Mingpan Cheng (1) , Jielin Chen (1) , Huangxian Ju (1) , David Monchaud (2) , Jean-Louis Mergny (3) , Jun Zhou (1)

1 NJU - Nanjing University
2 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
3 ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle

Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.

Domaines: Biochimie [q-bio.BM]

Jiawei Wang, Mingpan Cheng, Jielin Chen, Huangxian Ju, David Monchaud, et al.. An oxidatively damaged G-quadruplex/hemin DNAzyme. Chemical Communications, 2020, 56 (12), pp.1839-1842. ⟨10.1039/C9CC09237D⟩. ⟨hal-02475237⟩